dc.contributor.author | Delgado Vélez, Manuel | |
dc.contributor.author | Báez Pagán, Carlos A. | |
dc.contributor.author | Gerena, Yamil | |
dc.contributor.author | Quesada, Orestes | |
dc.contributor.author | Santiago Pérez, Laura I. | |
dc.contributor.author | Capó Vélez, Coral M. | |
dc.contributor.author | Wojna, Valerie | |
dc.contributor.author | Meléndez, Loyda | |
dc.contributor.author | León Rivera, Rosiris | |
dc.contributor.author | Silva, Walter I. | |
dc.contributor.author | Lasalde-Dominicci, José A. | |
dc.date.accessioned | 2022-09-15T20:41:35Z | |
dc.date.available | 2022-09-15T20:41:35Z | |
dc.date.issued | 2015-12-11 | |
dc.identifier.citation | Delgado-Vélez, M., Báez-Pagán, C.A., Gerena, Y., Quesada, O., Santiago-Pérez, L.I., Capó-Vélez, C.M., Wojna, V., Meléndez, L., León-Rivera, R., Silva, W. and Lasalde-Dominicci, J.A. (2015), The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clin Trans Immunol, 4: e53. https://doi.org/10.1038/cti.2015.31 | en_US |
dc.identifier.uri | https://hdl.handle.net/11721/2902 | |
dc.description.abstract | Antiretroviral therapy partially restores the immune system and markedly increases life expectancy of HIV-infected patients. However, antiretroviral therapy does not restore full health. These patients suffer from poorly understood chronic inflammation that causes a number of AIDS and non-AIDS complications. Here we show that chronic inflammation in HIV+ patients may be due to the disruption of the cholinergic anti-inflammatory pathway by HIV envelope protein gp120IIIB. Our results demonstrate
that HIV gp120IIIB induces α7 nicotinic acetylcholine receptor (α7) upregulation and a paradoxical proinflammatory phenotype in macrophages, as activation of the upregulated α7 is no longer capable of inhibiting the release of proinflammatory cytokines. Our results demonstrate that disruption of the cholinergic-mediated anti-inflammatory response can result from an HIV protein. Collectively, these findings suggest that HIV tampering with a natural strategy to control inflammation could contribute to a crucial, unresolved problem of HIV infection: chronic inflammation. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Australasian Society for Immunology | en_US |
dc.relation.ispartofseries | Clinical & Translational Immunology (2015), 4, e53 | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source.uri | https://onlinelibrary.wiley.com/doi/epdf/10.1038/cti.2015.31 | en_US |
dc.subject | Infections | en_US |
dc.subject | Human immunodeficiency virus | en_US |
dc.subject | HIV | en_US |
dc.subject | Chemokines | en_US |
dc.subject | Life span | en_US |
dc.subject | Mortality | en_US |
dc.subject | Phenotypes | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Lymphocyte | en_US |
dc.subject | Chronic infection | en_US |
dc.subject | Nervous system | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Acquired immune deficiency syndrome | en_US |
dc.subject | AIDS | en_US |
dc.subject | Immune system | en_US |
dc.subject | Macrophages | en_US |
dc.subject | Cell activation | en_US |
dc.subject | Drug therapy | en_US |
dc.subject | Alzheimers disease | en_US |
dc.subject | Statistical analysis | en_US |
dc.subject | Antiretroviral therapy | en_US |
dc.subject | Viral envelope proteins | en_US |
dc.subject.lcsh | AIDS (Disease)--Patients | en_US |
dc.subject.lcsh | HIV-positive--Medical care | en_US |
dc.subject.lcsh | Nicotinic receptors | en_US |
dc.subject.lcsh | HIV infections--Immunotherapy | en_US |
dc.title | The α7‐nicotinic receptor is upregulated in immune cells from HIV‐seropositive women : consequences to the cholinergic anti‐inflammatory response | en_US |
dc.type | Article | en_US |
dc.description.version | TBD | en_US |
dc.rights.holder | ©2015, Manuel Delgado Vélez | en_US |
dc.contributor.campus | University of Puerto Rico, Río Piedras Campus | en_US |
dc.description.discipline | Chemistry | en_US |
dc.description.other-discipline | Biology | en_US |