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Analysis of prediction errors in partial least squares calibration models using near infrared spectroscopy by three experimental systems
(2019-05-14)
This dissertation is focused on understanding the absorption and scattering effects of solid materials in the near infrared (NIR) spectral region and their impact on the prediction errors observed in NIR calibration models ...
Development, validation, and implementation of NIR calibration models in a commercial continuous manufacturing process
(2017)
Near infrared spectroscopy is a very promising non-invasive technique since it allows the use of calibration models to monitor physical and chemical properties of raw materials, intermediate products (blend), and the end ...
Evaluation of sources of error in dynamic processes and material traceability in continuous pharmaceutical manufacturing through real-time spectroscopic analysis
(2021-05-05)
This dissertation focuses on the development of real-time spectroscopic methods to investigate the sources of variation in dynamic processes using variographic analysis and accomplish material traceability for continuous ...
Development of Blend Uniformity Determination Methodologies in Continuous Pharmaceutical Manufacturing Processes using Near- Infrared Spectroscopy
(2020-04-17)
Pharmaceutical companies are responsible for the development of their own blend uniformity specifications and guidelines to assure uniformity and homogeneity. Blend uniformity is a critical in the manufacturing of solid ...