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Synthesis, characterization, binding interactions with biomolecules and cytotoxic studies of molybdebocene complexes
(2009)
Bis-(cyclopentadienyl) molybdenum dichloride or molybdenocene dihalides, like other metallocenes dihalides, have shown antitumor properties in different human tumors. In contrast to titanocene dichloride, molybdenocene ...
Síntesis y estudios mecanísticos de complejos de molibdenoceno: Interacción de agentes metálicos anti-cáncer con el transporte de proteínas
(2012)
Nuevos complejos organometálicos fueron sintetizados, partiendo del dicloruro de molibdenoceno (Cp2MoCl2) y cuatro ligandos: L-Acido ascórbico(L-AA), 6-o-palmitoil-L- acido ascórbico (PAA), Etil maltol y D-penicilamina, ...
Synthesis, chemical and biochemical characterization of TiIV and VIV complexes with anti-tumor activity
(2010)
At the present time in which the metallocene dihalides have shown to possess antitumoral activity, scientists of all around the world have been working with the synthesis and structural modifications to improve their ...
Synthesis, characterization, cytotoxic activity and biological interactions of tungstenocene (lv) derivatives
(2012)
The design of medicinal compounds for cancer therapy is still a challenge. Organometallics offer a wide variety of promising anticancer drug candidates but this field is largely unexplored. This study has been focused on ...
Supramolecular host-guest interactions of cyclodextrins and calixarenes with niobocene and vanadocene
(2010)
Cyclodextrins (CDs) and calixarenes act as a molecular host to a variety of guests: ions, metal complexes, polar and nonpolar organic molecules. These inclusion complexes have found pharmaceutical applications due to the ...
Synthesis, characterization, cytotoxic studies of [(η5-C5H5)2Mo (thionucleobase/thionucleoside)]Cl complexes on cancer cell lines and their interaction with human serum albumin
(2010)
Molybdenocene dichloride like some other metallocene dihalides Cp2MX2 (M = Ti, V, Nb, Mo and X = halides) have shown high antiproliferative properties against a wide range of murine and human tumors. They also exhibit less ...
Structure-activity studies, role of transferrin, and gene expression profile of the cytotoxic activity of Ti(IV) complexes in colon adenocarcinoma
(2008-12)
Ligand modification on titanocene dichloride has the potential to produce soluble and stable complexes. As part of our research efforts in the area of titanium-based antitumor agents, we have investigated the cytotoxic ...