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Decoding Pathogenesis of Slow-Channel Congenital Myasthenic Syndromes using Recombinant Expression and Mice Models
(Puerto Rico Health Sciences Journal, 2010-03)
Despite the fact that they are orphan diseases, congenital myasthenic syndromes (CMS) challenge those who suffer from it by causing fatigable muscle weakness, in the most benign cases, to a progressive wasting of muscles ...
Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis
(Nature Publishing Group, 2016-01-14)
In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic ...
Visceral Regeneration in a Sea Cucumber Involves Extensive Expression of Survivin and Mortalin Homologs in the Mesothelium
(BioMed Central, 2010)
Background: The proper balance of cell division and cell death is of crucial importance for all kinds of developmental processes and for maintaining tissue homeostasis in mature tissues. Dysregulation of this balance often ...
The α7-nicotinic Receptor is Upregulated Inimmune Cells from HIV-seropositive Women: Consequences to the Cholinergic Anti-inflammatory Response.
(Nature Publishing Group, 2015-12-11)
Antiretroviral therapy partially restores the immune system and markedly increases life expectancy of HIV-infected patients. However, antiretroviral therapy does not restore full health. These patients suffer from poorly ...
Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments
(The Journal of Membrane Biology, 2008-05)
The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively
characterized over the last three decades. However, the molecular mechanisms by which detergents
influence membrane protein ...
Occurrence and correlates of overweight and obesity among island Puerto Rican youth
(International Society on Hypertension in Blacks, 2011)
Objective & Main Outcome Measures:
This paper provides 2005–08 population-based prevalence data on obesity and overweight among youth residing in Puerto Rico.
Erasing fear memories with extinction training
(2010)
Decades of behavioral studies have confirmed that extinction does not erase classically conditioned fear memories. For this reason, research efforts have focused on the mechanisms underlying the development of extinction-induced ...
GRACE (Gender, Race And Clinical Experience): 48-week results of darunavir/r-based therapy in the largest trial in north america to focus on treatment-experienced women
(2009-07-19)
Women account for an increasing proportion of patients living with HIV/AIDS in the United States (US) yet data on the efficacy and safety of antiretrovirals (ARVs) in women are limited.
– Several challenges, including ...
Aromaticity at the Water-Hydrocarbon Core Interface of the Membrane: Consequences on the Nicotinic Acetylcholine Receptor
(Taylor & Francis, 2008-05-02)
Almost all lipid-exposed transmembrane domains of integral proteins contain aromatic residues flanking the hydrophobic segment of the domains. These residues generally reside close to the carbonyl region of the membrane, ...
Calbindin-D32k Is Localized to a Subpopulation of Neurons in the Nervous System of the Sea Cucumber Holothuria glaberrima (Echinodermata).
(Public Library of Science (PLOS), 2012-03-07)
Members of the calbindin subfamily serve as markers of subpopulations of neurons within the vertebrate nervous system. Although markers of these proteins are widely available and used, their application to invertebrate ...