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Aromaticity at the water-hydrocarbon core interface of the membrane: Consequences on the nicotinic acetylcholine receptor
(Channels (Austin), 2008)
Almost all lipid-exposed transmembrane domains of integral proteins contain aromatic residues
flanking the hydrophobic segment of the domains. These residues generally reside close to the
carbonyl region of the membrane, ...
Heterogeneous Generation of New Cells in the Adult Echinoderm Nervous System
(Frontiers Media S.A., 2015-09-22)
Adult neurogenesis, generation of new functional cells in the mature central nervous system (CNS), has been documented in a number of diverse organisms, ranging from humans to invertebrates. However, the origin and evolution ...
Adiponectin expression and the cardioprotective role of the vitamin D receptor activator paricalcitol and the angiotensin converting enzyme inhibitor enalapril in ApoE-deficient mice
(SAGE Publications Open Access, 2014-12)
Background—Coronary heart disease (CHD) is the number one cause of death in the US. The adipokine adiponectin has been studied intensively for presenting and inversed association with almost every stage of CHD. For instance, ...
Tryptophan Scanning Mutagenesis of the γM4 Transmembrane Domain of the Acetylcholine Receptor from Torpedo californica
(American Society for Biochemistry and Molecular Biology, 2004-10)
The periodicity of structural and functional effects induced by tryptophan scanning mutagenesis has been
successfully used to define function and secondary structure of various transmembrane domains of the acetylcholine ...
Triiodothyronine (T3) action on aquatic locomotor behavior during metamorphosis of the bullfrog Rana catesbeiana
(The International Journal of Developmental Biology, 2009)
Thyroid hormones - particularly triiodothyronine, T3 - play a critical role in the morphological
transformations comprising metamorphosis in larval bullfrogs (Rana catesbeiana). Traditional
staging criteria for anuran ...
Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies.
(Nature / Scientific Reports, 2016-09-19)
This study compares the lipid composition, including individual phospholipid molecular species of solubilized nAChR detergent complexes (nAChR-DCs) with those of the bulk lipids from their source, Torpedo californica (Tc) ...
Revisiting the role of infralimbic cortex in fear extinction with optogenetics
(Society for Neuroscience., 2015)
Previous rodent studies have implicated the infralimbic (IL) subregion of the medial prefrontal cortex in extinction of auditory fear conditioning. However, these studies used pharmacological inactivation or electrical ...
Reduced functional connectivity within the mesocorticolimbic system in substance use disorders: An fMRI study of Puerto Rican young adults
(Frontiers Media, 2016-05)
Studies of the mesocorticolimbic reward system (MCLS) and its relationship with impulsivity and substance use disorders (SUD) have largely focused on individuals from non-minority backgrounds. This represents a significant ...
Disparities in asthma medication dispensing patterns: The case of pediatric asthma in Puerto Rico
(Tylor and Francis, 2010)
BACKGROUND—Disparities exist in asthma medication dispensing between children with public insurance and those with private insurance under a Managed Care Medicaid system in Puerto Rico.
SNPs in the lysyl oxidase-like protein 4 (LOXL4) and complement component 3 (C3) genes are associated with increased risk for endometriosis and endometriosis-associated Infertility
(Elsevier, 2011-08)
This study was conducted to assess genetic associations to endometriosis in a Puerto Rican population. Significant differences in allelic frequencies and genotype distribution of genetic variants in LOXL4 and C3 were ...