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Analysis of prediction errors in partial least squares calibration models using near infrared spectroscopy by three experimental systems
(2019-05-14)
This dissertation is focused on understanding the absorption and scattering effects of solid materials in the near infrared (NIR) spectral region and their impact on the prediction errors observed in NIR calibration models ...
Development, validation, and implementation of NIR calibration models in a commercial continuous manufacturing process
(2017)
Near infrared spectroscopy is a very promising non-invasive technique since it allows the use of calibration models to monitor physical and chemical properties of raw materials, intermediate products (blend), and the end ...
A diffuse reflectance NIR spectroscopy method for determine drug concentration in pharmaceutical production tablets based on a PLS calibration model from manufactured tablets
(2018-05)
A diffuse reflectance near-infrared (NIR) spectroscopy method was developed to determine the active pharmacological ingredient (API) in pharmaceutical production tablets from batch and continuous manufacturing processes.
Tablets ...
Development of Blend Uniformity Determination Methodologies in Continuous Pharmaceutical Manufacturing Processes using Near- Infrared Spectroscopy
(2020-04-17)
Pharmaceutical companies are responsible for the development of their own blend uniformity specifications and guidelines to assure uniformity and homogeneity. Blend uniformity is a critical in the manufacturing of solid ...