Mostrar el registro sencillo del ítem

dc.contributor.authorQuirk, Gregory J.
dc.contributor.authorParé, Denis
dc.contributor.authorRichardson, Rick
dc.contributor.authorCyril, Herry
dc.contributor.authorMonfils, Marie H.
dc.contributor.authorSchiller, Daniela
dc.contributor.authorVicentic, Aleksandra
dc.date.accessioned2017-05-25T16:20:50Z
dc.date.available2017-05-25T16:20:50Z
dc.date.issued2010
dc.identifier.citationQuirk, G. J., Paré, D., Richardson, R., Herry, C., Monfils, M. H., Schiller, D., & Vicentic, A. (2010). Erasing fear memories with extinction training. The Journal of Neuroscience, 30(45), 14993–14997. http://doi.org/10.1523/JNEUROSCI.4268-10.2010en_US
dc.identifier.issn0270-6474
dc.identifier.urihttp://hdl.handle.net/11721/1605
dc.descriptionSymposiumen
dc.description.abstractDecades of behavioral studies have confirmed that extinction does not erase classically conditioned fear memories. For this reason, research efforts have focused on the mechanisms underlying the development of extinction-induced inhibition within fear circuits. However, recent studies in rodents have uncovered mechanisms that stabilize and destabilize fear memories, opening the possibility that extinction might be used to erase fear memories. This symposium focuses on several of these new developments, which involve the timing of extinction training. Extinction-induced erasure of fear occurs in very young rats, but is lost with the development of perineuronal nets in the amygdala that render fear memories impervious to extinction. Moreover, extinction administered during the reconsolidation phase, when fear memory is destabilized, updates the fear association as safe, thereby preventing the return of fear, in both rats and humans. The use of modified extinction protocols to eliminate fear memories complements existing pharmacological strategies for strengthening extinction.en_US
dc.description.sponsorshipGrant support: P50 MH086400/MH/NIMH NIH HHS/United States R01 MH058883/MH/NIMH NIH HHS/United States R01 MH081975/MH/NIMH NIH HHS/United States R01 MH091147/MH/NIMH NIH HHS/United Statesen_US
dc.language.isoen_USen_US
dc.subjectFearen_US
dc.subjectExtinction trainingen_US
dc.subjectFear memoriesen_US
dc.subject.meshConditioning, Classical/physiologyen
dc.subject.meshConditioning, Classical/physiologyen
dc.subject.meshFear/physiologyen
dc.subject.meshMemory/physiologyen
dc.titleErasing fear memories with extinction trainingen_US
dc.typeArticleen_US
dc.description.FacultySchool of Medicineen_US
dc.description.DepartmentDepartment of Medicineen_US
dc.description.doidoi: 10.1523/JNEUROSCI.4268-10.2010en
dc.contributor.campusUniversity of Puerto Rico, Medical Science Campus


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Excepto si se señala otra cosa, la licencia del ítem se describe como All Rights Reserved