Mostrar el registro sencillo del ítem
The α7-nicotinic Receptor is Upregulated Inimmune Cells from HIV-seropositive Women: Consequences to the Cholinergic Anti-inflammatory Response.
dc.contributor.author | Delgado-Vélez, Manuel | |
dc.contributor.author | Báez-Pagán, Carlos A. | |
dc.contributor.author | Gerena, Yamil | |
dc.contributor.author | Quesada, Orestes | |
dc.contributor.author | Santiago-Pérez, Laura I. | |
dc.contributor.author | Capó-Vélez, Coral M. | |
dc.contributor.author | Wojna, Valerie | |
dc.contributor.author | Meléndez, Loyda | |
dc.contributor.author | León-Rivera, Rosiris | |
dc.contributor.author | Silva, Walter | |
dc.contributor.author | Lasalde-Dominicci, José A. | |
dc.date.accessioned | 2017-03-23T20:57:37Z | |
dc.date.available | 2017-03-23T20:57:37Z | |
dc.date.copyright | © 2015 Australasian Society for Immunology Inc. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.date.issued | 2015-12-11 | |
dc.identifier | Clinical and Translational Immunology | en_US |
dc.identifier.citation | Delgado-Vélez, M., Báez-Pagán, C. A., Gerena, Y., Quesada, O., Santiago-Pérez, L. I., Capó-Vélez, C. M., … Lasalde-Dominicci, J. A. (2015). The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clinical & Translational Immunology, 4(12), e53–. http://doi.org/10.1038/cti.2015.31 | en_US |
dc.identifier.issn | 2050-0068 | |
dc.identifier.uri | http://hdl.handle.net/11721/1567 | |
dc.description.abstract | Antiretroviral therapy partially restores the immune system and markedly increases life expectancy of HIV-infected patients. However, antiretroviral therapy does not restore full health. These patients suffer from poorly understood chronic inflammation that causes a number of AIDS and non-AIDS complications. Here we show that chronic inflammation in HIV+ patients may be due to the disruption of the cholinergic anti-inflammatory pathway by HIV envelope protein gp120IIIB. Our results demonstrate that HIV gp120IIIB induces α7 nicotinic acetylcholine receptor (α7) upregulation and a paradoxical proinflammatory phenotype in macrophages, as activation of the upregulated α7 is no longer capable of inhibiting the release of proinflammatory cytokines. Our results demonstrate that disruption of the cholinergic-mediated anti-inflammatory response can result from an HIV protein. Collectively, these findings suggest that HIV tampering with a natural strategy to control inflammation could contribute to a crucial, unresolved problem of HIV infection: chronic inflammation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.title | The α7-nicotinic Receptor is Upregulated Inimmune Cells from HIV-seropositive Women: Consequences to the Cholinergic Anti-inflammatory Response. | en_US |
dc.type | Article | en_US |
dc.rights.licence | © 2015 Australasian Society for Immunology Inc. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
dcterms.rights | © 2015 Australasian Society for Immunology Inc. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
dcterms.rightsHolder | © 2015 Australasian Society for Immunology Inc. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.identifier.doi | 10.1038/cti.2015.31 | en_US |
dc.local.Faculty | College of Natural Sciences | en_US |
dc.local.department | Department of Chemistry | en_US |
dc.contributor.campus | University of Puerto Rico, Río Piedras Campus |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Faculty Research Works
Trabajos académicos e investigaciones
Excepto si se señala otra cosa, la licencia del ítem se describe como © 2015 Australasian Society for Immunology Inc.
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/