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Effects of Lipid-Analog Detergent Solubilization on the Functionality and Lipidic Cubic Phase Mobility of the Torpedo californica Nicotinic Acetylcholine Receptor
(The Journal of Membrane Biology, 2012)
Over the past three decades, the Torpedo californica nicotinic acetylcholine receptor (nAChR) has
been one of the most extensively studied membrane protein systems. However, the effects of
detergent solubilization on ...
Aromaticity at the water-hydrocarbon core interface of the membrane: Consequences on the nicotinic acetylcholine receptor
(Channels (Austin), 2008)
Almost all lipid-exposed transmembrane domains of integral proteins contain aromatic residues
flanking the hydrophobic segment of the domains. These residues generally reside close to the
carbonyl region of the membrane, ...
Tryptophan Scanning Mutagenesis of the γM4 Transmembrane Domain of the Acetylcholine Receptor from Torpedo californica
(American Society for Biochemistry and Molecular Biology, 2004-10)
The periodicity of structural and functional effects induced by tryptophan scanning mutagenesis has been
successfully used to define function and secondary structure of various transmembrane domains of the acetylcholine ...
Triiodothyronine (T3) action on aquatic locomotor behavior during metamorphosis of the bullfrog Rana catesbeiana
(The International Journal of Developmental Biology, 2009)
Thyroid hormones - particularly triiodothyronine, T3 - play a critical role in the morphological
transformations comprising metamorphosis in larval bullfrogs (Rana catesbeiana). Traditional
staging criteria for anuran ...
Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies.
(Nature / Scientific Reports, 2016-09-19)
This study compares the lipid composition, including individual phospholipid molecular species of solubilized nAChR detergent complexes (nAChR-DCs) with those of the bulk lipids from their source, Torpedo californica (Tc) ...
Decoding Pathogenesis of Slow-Channel Congenital Myasthenic Syndromes using Recombinant Expression and Mice Models
(Puerto Rico Health Sciences Journal, 2010-03)
Despite the fact that they are orphan diseases, congenital myasthenic syndromes (CMS) challenge those who suffer from it by causing fatigable muscle weakness, in the most benign cases, to a progressive wasting of muscles ...
The α7-nicotinic Receptor is Upregulated Inimmune Cells from HIV-seropositive Women: Consequences to the Cholinergic Anti-inflammatory Response.
(Nature Publishing Group, 2015-12-11)
Antiretroviral therapy partially restores the immune system and markedly increases life expectancy of HIV-infected patients. However, antiretroviral therapy does not restore full health. These patients suffer from poorly ...
Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments
(The Journal of Membrane Biology, 2008-05)
The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively
characterized over the last three decades. However, the molecular mechanisms by which detergents
influence membrane protein ...
Aromaticity at the Water-Hydrocarbon Core Interface of the Membrane: Consequences on the Nicotinic Acetylcholine Receptor
(Taylor & Francis, 2008-05-02)
Almost all lipid-exposed transmembrane domains of integral proteins contain aromatic residues flanking the hydrophobic segment of the domains. These residues generally reside close to the carbonyl region of the membrane, ...
Biophysical and Ion Channel Functional Characterization of the Torpedo Californica Nicotinic Acetylcholine Receptor in Varying Detergent-Lipid Environments
(Springer-Verlag, 2009-05-01)
The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively characterized over the last three decades. However, the molecular mechanisms by which detergents influence membrane protein stability ...