Now showing items 1-6 of 6
Analysis of prediction errors in partial least squares calibration models using near infrared spectroscopy by three experimental systems
This dissertation is focused on understanding the absorption and scattering effects of solid materials in the near infrared (NIR) spectral region and their impact on the prediction errors observed in NIR calibration models ...
Development of a methodology to determine drug distribution in polymeric thin film formulations using hyperspectral image analysis
This dissertation is focused on the development of analytical methods to determine drug distribution throughout polymeric films using hyperspectral image analysis. The NIR-CI and Raman mapping techniques have been used to ...
Development, validation, and implementation of NIR calibration models in a commercial continuous manufacturing process
Near infrared spectroscopy is a very promising non-invasive technique since it allows the use of calibration models to monitor physical and chemical properties of raw materials, intermediate products (blend), and the end ...
Development of near infrared spectroscopic methods to predict and understand dissolution of solid oral dosage forms
Shear stress is created in a system by moving one surface over another to cause displacements in the direction of the moving surface. Shearing of powder is essential to break down agglomerates in cohesive powders, promoting ...
Development of near infrared spectroscopy methodologies to provide physical information for pharmaceutical processes
This research focused on increasing the number of applications and establishing methods to monitor physical properties from pharmaceutical materials using Near Infrared Spectroscopy (NIRS). NIRS in combination with chemometric ...
Development of Blend Uniformity Determination Methodologies in Continuous Pharmaceutical Manufacturing Processes using Near- Infrared Spectroscopy
Pharmaceutical companies are responsible for the development of their own blend uniformity specifications and guidelines to assure uniformity and homogeneity. Blend uniformity is a critical in the manufacturing of solid ...