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Examination of the effect of PEG-Rich matrices in Multi Drug Resistance-Associated Protein (MRP) and Multi Drug Resistance (MDR) substrates transport utilizing the CaCo-2 Cell Model
(2008)
Multidrug resistance (MDR) is responsible for the low absorption of a very wide range of drugs and has been recognized as one of the major hurdles in drug absorption. Crosslinked poly(ethylene glycol) based morphologies ...
Assessment of the stability and biological activity of our model proteins encapsulated in hydrogel membranes
(2007)
Proteins are biological macromolecules which have a unique spatial conformation. This spatial conformation can be affected by extremes in pH, temperature, and organic solvents. Once this 3D spatial conformation is affected ...
Carboxymethylation of dextran for surface modification of magnetite nanoparticles
(2009)
Magnetite nanoparticles are currently studied for biomedical applications such as MRI, drug delivery, and magnetic fluid hyperthermia (MHF). These applications require nanoparticles with a suitable coating which provides ...
Design of composite protein microcrystals for the sustained oral delivery of antigens
(2015)
Oral immunization is a promising method to decrease access of allergens and pathogens to the body. Oral delivery of antigens is challenged by the anatomical conditions of the gastrointestinal tract, such as degradation by ...
Development of optimized therapeutic platforms for magnetic fluid hyperthermia in adjuvant cancer therapies
(2018-05)
Magnetic Fluid Hyperthermia (MFH) has a great potential as an adjuvant in cancer therapy, enhancing the
effects of antineoplastic agents, sensitizing resistant cancers and reducing undesired side effects. When
compared ...
Immobilization of myoglobin from horse skeletal muscle (Mb) and hemoglobin (Hb1) from Lucina pectinata in hydrophilic polymer networks for H2S biosensor application
(2005)
Hemeproteins are known for their spectroscopic properties which change during
the binding of specific ligands. This project envisioned the immobilization of myoglobin
from horse skeletal muscle (Mb) and hemoglobin I from ...
Enhanced potentiation of anticancer drugs using magnetic fluid hyperthermia (MFH): In vitro and in vivo studies
(2014)
Clinical studies have demonstrated the effectiveness of combined hyperthermia and anticancer drug treatments. Challenges related to effective heat transfer have limited its clinical application. The use of magnetic fluids ...
Studies of ferrite based magnetic nanoparticle uptake and magnetocytolysis effects on model cell cultures
(2009)
Suspended ferrite magnetic nanoparticles are known to dissipate energy under an oscillating magnetic field. Such energy dissipation could be employed to locally raise temperature inside a tumor to 41-45°C (hyperthermia), ...
Use of crosslinked hydrogels for the control of macromolecular crystallization
(2012)
Crosslinked hydrogels in protein crystallization is an area of continuous growth. The counterdiffusion technique is a novel method for the crystallization of proteins, which entails the minimization of convection effects, ...
Encapsulation of particles in crosslinked hydrogel networks: particles distribution optimization
(2010)
Particle encapsulation in polymer systems has been used in several industrial applications in the biomedical and pharmaceutical fields. The main challenge in particle encapsulation is to obtain a homogeneous particle ...