Parvoviruses are small, non-enveloped, icosahedral viruses that contain a linear, single-stranded DNA genome of approximately 5000 bp. Parvovirus LuIII is an autonomous parvovirus that shares up to 80% of sequence homology ...

Studies to elucidate the mechanism of parvoviral replication are ongoing due to their potential as transient vectors for human gene therapy. Parvovirus LuIII, a single stranded DNA virus, has short double-stranded hairpin ...

LuIII is a small, non-enveloped, icosahedral autonomous parvovirus that contains a small linear (5 kb) single stranded DNA genome and infects human cell lines lytically with no evidence of integration into cellular DNA. ...

The synthesis of minus strand by parvovirus LuIII requires replication from the left palindrome of the plus strand DNA. An origin of replication yet to be identified must be present at the right end of the minus strand, ...

The replication of autonomous parvovirus LuIII and its encapsidation pattern have not been fully explained. Two genomic clones of LuIII, pBLu(+) and pBLu(-), were constructed. These clones were used to produce the (+) ...