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Development of calibration models for the in-line prediction of active pharmaceutical ingredient concentration in the range 0-100% W/W by near infrared and Raman spectroscopy
(2013)
The development of quantitative calibration models by near infrared (NIR) and Raman spectroscopy with the capability of predicting concentration in a wider range than the currently used approach will be described. Current ...
Development of near infrared spectroscopy methodologies to provide physical information for pharmaceutical processes
(2013)
This research focused on increasing the number of applications and establishing methods to monitor physical properties from pharmaceutical materials using Near Infrared Spectroscopy (NIRS). NIRS in combination with chemometric ...
Development of a calibration model to determine drug concentration in pharmaceutical mixtures
(2011)
A robust calibration model was created using Near Infrared Spectroscopy (NIR) and by minimizing the correlation between the active pharmaceutical ingredient (API) and components in a pharmaceutical process. An experimental ...
Diffracted light contrast: A chemical application
(2010)
There is a tremendous interest in the development of microscopy tools that can provide important information at a cost significantly smaller than those offered by traditional electron microscopes. With the purpose of ...
Desarrollo de método cuantitativo para la determinación del contenido de humedad en el proceso de granulación de un medicamento utilizando la tecnología de infrarrojo cercano
(2011)
The granulation process is one of the most important processes in the manufacture of a pharmaceutical product. This is due to that in this manufacturing step the active ingredient (AI) is mixed with the excipients. One ...
Near infrared spectroscopic transmission measurements for pharmaceutical powder mixtures and theory of sampling (TOS) applied in pharmaceutical industry quality control (Qc) practices
(2015)
This thesis presents two projects that involve the implementation of near infrared spectroscopy. NIR spectroscopy is a fast and non-destructive spectroscopy that in combination with multivariate analysis is a very useful ...
Development of a methodology to determine drug distribution in polymeric thin film formulations using hyperspectral image analysis
(2013)
This dissertation is focused on the development of analytical methods to determine drug distribution throughout polymeric films using hyperspectral image analysis. The NIR-CI and Raman mapping techniques have been used to ...