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Modeling and control of continuous tumble mixing of granular materials
(2005-06)
An approach to automatic control of a continuous tumble mixer of powders is presented. The control system is based on an ideal model that describes the mixer dynamics where the controlled variables are the outlet flow from ...
Effect of operational and design parameters on the early stages of high shear wet granulation processes
(2014)
The development of new technologies, active ingredients and regulatory initiatives, has increased the need for a scientific understanding of the pharmaceutical manufacturing processes. In this context, solid dosage forms ...
Experimental and numerical study of the continuous fluidized bed dryer
(2016)
Nowadays, batch fluid-bed drying is one of the most efficient drying methods for particulate material; but at the same time, it is the most energy consuming operation in the manufacturing of solid dosage forms. To minimize ...
Effect of impeller speed on particle size distribution during high shear wet granulation process
(2010)
Wet granulation is the process where powders are mixed with a binder agent which is agitated with a mixer and forms a granulated product. This process is commonly used to better the processing characteristics of a powdered ...
Functionalization of inhalable particles by fluidized bed processing
(2008)
This work focused initially on the size reduction of naproxen sodium to less than 5 µm for inhalation applications. The second objective was the adhesion of naproxen sodium particles to micronized lactose particles with ...
Determination of an empirical correlation for the mass transfer coefficients of pharmaceutical powders in a fluid bed layer
(2004)
The pharmaceutical industry has four basic operations to produce tablets: mixing, drying,
milling, and tablet pressing. Fluidized bed drying of the pharmaceutical powders is one of
the most efficient methods, which is ...
Mixing of granular materials in an oscillatory shear mixer
(2009)
Mezclado es uno de los pasos más importantes en el manejo de los polvos en muchas industrias tales como en la industria química, metalúrgica, farmacéutica, alimenticia, etc., debido al gran efecto que tiene en la composición ...
Effect of initial formulation conditions, process parameters and equipment design on wet granulation
(2020-07-24)
Ease of administration and handling are some of the reasons to keep solid oral dosage forms as the presentation of predilection for today’s medicines. Today, pharmaceutical companies are looking for more efficient processes ...
Improving continuous manufacturing process reliability through feeding control system
(2018-12-12)
Continuous manufacturing processes are complex systems composed of multiple unit operations where process variables and material properties interaction allow the development of soft PAT sensors. Hence, this study was focused ...
Modeling of growth kinetics of wet granulation in a high shear mixer by means of image processing and analysis
(2006)
Wet granulation is one of the most important operations where fine particles are
agglomerated into larger granules by adding a binder. The process is used in many chemical
industries including pharmaceutical, mineral ...