SNPs in the lysyl oxidase-like protein 4 (LOXL4) and complement component 3 (C3) genes are associated with increased risk for endometriosis and endometriosis-associated Infertility

Abstract

This study was conducted to assess genetic associations to endometriosis in a Puerto Rican population. Significant differences in allelic frequencies and genotype distribution of genetic variants in LOXL4 and C3 were documented in patients with endometriosis-associated infertility vs controls, and in patients with endometriosis vs controls, respectively, and in women having the risk genotype at both SNPs, the estimated risk for endometriosis nearly doubled.